By Charu Bahri

Mar 31 (IANS): Food is comforting, it can be a heady gastronomical experience, and many traditional systems of medicine believe various foods can help prevent and cure disease. Now, new research is confirming that foods containing probiotics -- health-enhancing live micro-organisms such as bacteria and yeasts -- and prebiotics -- non-digestible plant fibres that promote the growth of probiotics -- can complement and, in some cases, even replace medicine.

Gut microbiota, the collection of symbiotic micro-organisms in our digestive tract, is known to play a crucial role in our digestive health, and is implicated in a range of diseases including asthma and diabetes. And pre- and probiotics-rich foods and supplements help maintain an optimal ecology of such micro-organisms, which offers a wide range of health benefits.

An April 2016 study published in Minerva Urologica e Nefrologica says chronic kidney disease patients who took prebiotic and probiotic supplements thrice daily for six months, in addition to a low protein diet, maintained their estimated glomerular filtration rate -- a desirable kidney function indicator -- at more than three times the level of those taking a low protein diet alone.

"This would slow the progression of chronic kidney disease, which typically ends in end-stage renal disease, necessitating periodical dialysis and shortening the lifespan," Pavan Malleshappa, lead researcher and head, Division of Nephrology, Department of Medicine, Adichunchanagiri Institute of Medical Sciences, Karnataka, told IndiaSpend.

This study has important implications for India, where chronic kidney disease was the eighth-leading cause of death in 2015, according to a Global Burden of Disease study.

The benefits of pre- and probiotics are even more remarkable in fighting diarrhoea, a leading public health challenge in India that claims the lives of 13 children below five years every hour, or 328 children every day.

Over 12 weeks, the daily consumption of a probiotic drink containing Lactobacillus casei Shirota -- named for Japanese scientist Minoru Shirota, who isolated it in 1930 -- reduced the occurrence of acute diarrhoea in young slum-dwelling children in Kolkata by 14 per cent, according to a June 2011 study published in Epidemiology and Infection.

Probiotics can favourably impact high cholesterol and insulin resistance -- precursors of heart disease and diabetes, respectively, which the Global Burden of Disease study ranked as the top and seventh cause of death in India.

They can also help alleviate constipation, which one in seven Indians suffers from, as well as indigestion, which afflicts three in 10.

Lata Pathak, 71, a Mumbai housewife, developed sluggish bowel movements and heartburn four years ago. These complaints exacerbated her diabetes, which she had managed to control well for over a decade with dietary precautions and medication.

"I used herbal potions for the constipation, but wanted to come off those because they are habit-forming," she told IndiaSpend. A dietician prescribed, simply: 30 grams of oats, three servings of curd and one elchi (dwarf) banana daily.

It did the trick. Pathak has not needed the herbal potions since. "My constipation and acidity are gone and my blood glucose readings are better than before," she said.

Homemade curd contains the bacteria Lactobacillus acidophilus in an optimal measure to boost digestion, Suvarna Pathak, consulting dietician coordinator at Nanavati Super Speciality Hospital, Mumbai, told IndiaSpend.

Oats added the soluble fibre betaglucan to Pathak's diet, while elchi bananas added inulin, a class of dietary fibre called fructans that spur the growth of good bacteria and boost their action. The prebiotics helped regularise bowel movements while the probiotics helped absorb nutrients.

Since prebiotics and probiotics work symbiotically, prescribing a combination of both makes sense. "However, combining both in one product is technically challenging," said Subhashis Basu, Business Head, Dairy Products, Mother Dairy Fruit & Vegetable. Packaged foods, therefore, usually contain either pre- or probiotics, although medical supplements often contain both.

To be effective, probiotics must reach the colon alive and in huge numbers. "A billion a day keeps your doctor away," quipped Virender Kumar Batish, secretary and founder, Probiotic Association of India and former head and emeritus professor, National Dairy Research Institute, Karnal. A 2016 Indian Journal of Public Health study recommended consuming 1×107 colony-forming units (cfu) of probiotics daily.

Amul's probiotic ice-cream, for instance, contains 1×106 cfu each of the popular probiotic strains Bifidobacterium lactis Bb-12 and Lactobacillus acidophilus La-5. A daily 54 gram serving has been shown to reduce the level of Streptococcus mutans -- salivary bacteria that cause dental caries -- in 6- to 12-year-olds by 12.5 per cent in just a week.

"The probiotics worked by replacing bad (disease-causing) bacteria with good... bacteria," said Taranatha Mahantesha, from the Department of Paediatric and Preventive Dentistry, Navodaya Dental College, Raichur.

For the Kolkata diarrhoea study, the team used Danone's readymade probiotic drink, Yakult, which contains 6.5x109 cfu of Lactobacillus casei Shirota.

The study on chronic kidney disease used capsules containing 15x109 cfu each of the Streptococcus thermophiles, Lactobacilllus acidophilus and Bifidobacterium longum, and 100 milligram of a prebiotic.

This supplement worked by modifying the intestinal microbiota of renal disease patients and thus reducing the production of uremic gut toxins, Malleshappa said, adding, "I now recommend probiotic and prebiotic supplements to chronic kidney disease patients who can afford them."

"All probiotics are associated with some core benefits like restoration of healthy gut flora disturbed as a result of infection, antibiotic consumption and poor diets," Batish says, adding, however, that their functional efficacy is highly strain-specific. This means that every culture has specific attributes, with certain strains being more efficient against conditions such as diarrhoea and diabetes, and potentially against neurological disorders such as autism, Parkinson's disease and schizophrenia.

Batish said there is huge scope to research the bacteria that have evolved in and effectively colonised Indian guts with a view to developing appropriate probiotic foods and supplements.

What this means for you, in brief, is you may need to consult a specialist to identify the pre- or probiotic foods or supplements best suited to your health needs, and the dosage.

"Depending on your calorific need, you could consume 6 to 12 servings of prebiotic-containing foods, with a couple of servings of probiotic foods," Pathak says.

Good sources of prebiotics include wheat bran, sweet potatoes, flaxseeds and yam.

Probiotics, to be effective, must be taken over a period of time -- the longer, the better.

"Based on our findings, if we had had the funds to continue the probiotic supplement for up to six months, the protective effect would have touched 30 per cent," said Dipika Sur, principal investigator of the Kolkata study on acute diarrhoea and former director-grade scientist, National Institute of Cholera and Enteric Diseases, Kolkata.

However, dosage must be chosen carefully because if taken in excess, probiotics can cause bloating and nausea. Also, not all packaged probiotic foods -- such as ice-cream -- are healthy like they claim to be.

"Our finding does not mean that eating probiotic ice-cream is a must," Mahantesha of the oral hygiene study, said. "Think of the unwanted calories from sugar... But if you or children must eat ice-cream, choose a probiotic variety."

Figuring out if a packaged probiotic food is too bacteria- or calorie-intense may become easier after January 1, 2018, when the Food Safety and Standards Authority of India's (FSSAI's) labelling requirements for eight categories of foods, including probiotics, come into effect.