Geneva, Apr 22 (IANS): The World Health Organisation (IANS) on Friday made a strong recommendation for Pfizer's antiviral for mild and moderate Covid-19 patients at highest risk of hospital admission.

The oral antiviral drug, which is a combination of nirmatrelvir and ritonavir tablets, "is the best therapeutic choice for high-risk patients to date", according to the global health body.

It strongly recommended for patients who are 12 years or older with non-severe Covid-19 who are at highest risk of developing severe disease and hospitalisation, such as unvaccinated, older, or immunosuppressed patients.

However, the WHO suggested against its use in patients at lower risk, as the benefits were found to be negligible.

The new recommendation by the WHO is based on new data from two randomised controlled trials involving 3,078 patients. The data show that the risk of hospitalisation is reduced by 85 per cent following this treatment. In a high-risk group (over 10 per cent risk of hospitalisation), that means 84 fewer hospitalisations per 1,000 patients.

Meanwhile, the WHO also called for wide geographical distribution and transparency from Pfizer.

The WHO stated that it "is extremely concerneda that -- as occurred with Covid-19 vaccines -- low- and middle-income countries will again be pushed to the end of the queue when it comes to accessing this treatment".

It said that availability, lack of price transparency in bilateral deals made by the producer, and the need for prompt and accurate testing before administering it, are turning this life-saving medicine into a major challenge for low- and middle-income countries.

Recent data from the US Department of Health revealed that nearly 600,000 courses of Pfizer's Paxlovid are currently sitting on pharmacy shelves unused, Daily Mail reported.

Experts suggest too few doctors are aware the treatments are available. In addition, lack of testing and pills limited to immunocompromised may explain its low usage, the report said

According to the WHO, one obstacle for low- and middle-income countries is that the medicine can only be administered while the disease is at its early stages. It called for prompt and accurate testing for a successful outcome with this therapy.

Further, lack of transparency on the part of Pfizer is making it difficult for public health organisations to obtain an accurate picture of the availability of the medicine, which countries are involved in bilateral deals and what they are paying.

In addition, a licensing agreement made by Pfizer with the Medicines Patent Pool limits the number of countries that can benefit from generic production of the medicine.