Daijiworld Media Network - Brisbane

Brisbane, Mar 24: Scientists in Australia are developing next-generation iron-based nanoparticles to enhance treatment for triple-negative breast cancer (TNBC), one of the most aggressive and difficult-to-treat forms of the disease.

Researchers from the University of Queensland’s Australian Institute for Bioengineering and Nanotechnology (AIBN) are working on ‘nano-adjuvants’ tiny particles small enough to fit thousands on a single strand of hair to strengthen the immune system's response against TNBC.

Unlike other breast cancers, TNBC lacks specific protein targets, making conventional treatments less effective. “Despite the promise of immunotherapy, its effectiveness against TNBC is extremely limited, leaving too many women without options. Our research aims to change that,” said Prof Yu Chengzhong from AIBN.

The nanoparticles are designed to boost T-cell activity, helping the immune system recognize and attack cancer cells more efficiently. Supported by a A$3 million ($1.89 million USD) National Health and Medical Research Council grant, this five-year project could lead to clinical applications for other hard-to-treat cancers like ovarian cancer.

With over two decades of expertise in nanomedicine, Yu believes this breakthrough could revolutionize cancer treatment. AIBN Director Alan Rowan added, “This research will push scientific boundaries to find innovative treatments, offering hope to women facing devastating outcomes.”