Daijiworld Media Network – New Delhi
New Delhi, Feb 18: GLP-1 receptor agonists, originally developed for type 2 diabetes, are now witnessing soaring demand for weight management, with drugs like Ozempic gaining widespread popularity, particularly on social media.
Ozempic is the brand name for semaglutide, a GLP-1 receptor agonist that mimics the hormone glucagon-like peptide-1 (GLP-1), which regulates blood sugar, insulin secretion and appetite. While the drug continues to be prescribed for diabetes, its off-label use for weight loss has surged globally.
A recent study published in the Journal of Medical Internet Research found that many users are willing to continue using Ozempic despite experiencing unpleasant side effects, primarily because of the weight loss benefits.
Instead of conducting a traditional clinical trial, researchers used “infoveillance,” analysing 60 anonymous public reviews from the website Drugs.com to understand real-world patient experiences with Ozempic for weight loss.
The study found that perceived effectiveness was the main factor driving satisfaction and continuation of treatment. Patients who reported significant weight loss or improvements in appetite and food cravings were more inclined to tolerate side effects.
Around 67 per cent of users reported a significant drop in appetite or food cravings. Many described a reduced desire for sugary and greasy foods, allowing them to eat less without feeling deprived.
Gastrointestinal issues such as nausea and vomiting were the most commonly reported side effects, though their severity varied. Importantly, these side effects did not significantly impact overall satisfaction or decisions to continue treatment in most cases.
However, individuals who experienced minimal weight loss or non-gastrointestinal side effects were more likely to discontinue the medication.
Common side effects associated with Ozempic include nausea, vomiting, diarrhoea, abdominal pain, constipation and fatigue. Less common but more serious side effects may include pancreatitis, kidney problems, allergic reactions and gallbladder issues.
Ozempic works in three primary ways. It stimulates the pancreas to release insulin when blood sugar levels are high, helping to control post-meal glucose spikes. It slows gastric emptying, which prolongs the feeling of fullness and reduces blood sugar fluctuations. It also acts on appetite-regulating centres in the brain to reduce hunger and cravings.
Health experts emphasise that individuals prescribed GLP-1 medications for diabetes should strictly follow medical advice. For those considering such medications solely for weight loss, they should be used as part of a broader strategy that includes balanced nutrition, regular physical activity and sustainable lifestyle changes.
While medications like Ozempic can aid weight reduction, experts caution that they should not be viewed as a standalone solution. Consulting a qualified healthcare professional before starting any weight loss medication remains essential to ensure safety and suitability.