Daijiworld Media Network – New Delhi

New Delhi, Feb 5: A recent study has revealed that poor management of cardiovascular-kidney-metabolic (CKM) syndrome could increase the risk of age-related macular degeneration (AMD), a leading cause of vision loss among older adults. The research highlights that advanced stages of CKM syndrome, especially when neglected, are associated with a significantly higher likelihood of developing AMD, regardless of genetic predisposition.

The study analysed data from 3,19,638 participants aged between 37 and 73, drawn from the UK Biobank, a repository of health records and biological samples. Participants were classified into five stages of CKM based on body mass index, waist circumference, and other related health conditions. The average age of participants was 56.3 years, with 51.7% being women.

Researchers observed that patients with high CKM severity and other comorbidities, such as stroke and peripheral artery disease, faced the greatest risk of developing AMD. While individuals with a high genetic predisposition to AMD had elevated risk, the impact of CKM on AMD was independent of genetics.

The study also explained potential mechanisms linking CKM to AMD, including oxidative stress and inflammation caused by metabolic syndrome—a key component of CKM—which are known to damage the retina. Neglect of CKM symptoms and inadequate treatment further exacerbated the risk.

While the research relied on health records rather than direct clinical examination, and participants were generally healthier than the broader population, the findings underscore the need for regular screening and management of CKM syndrome to protect long-term vision.

Experts say the study emphasizes proactive healthcare, highlighting that maintaining cardiovascular, kidney, and metabolic health is crucial not just for overall well-being but also to prevent vision-related complications later in life.