Daijiworld Media Network - New Delhi
New Delhi, Apr 13: A new study published in the Gut journal has found that obesity in both parents before conception may significantly increase the risk of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in their children later in life.
The research, which analysed data from over 1,900 young adults, established a strong link between parental body mass index (BMI) and the likelihood of fatty liver disease in offspring.
According to Dr Isha Wadhawan, Attending Consultant in Obstetrics and Gynaecology, the findings underline a clear pattern. Each unit increase in maternal BMI was associated with a 10 per cent rise in risk, while paternal BMI increase raised the risk by 9 per cent. Notably, if both parents were overweight or obese, the child’s risk more than tripled.
MASLD, earlier known as non-alcoholic fatty liver disease, occurs when excess fat accumulates in the liver. It is currently the most prevalent chronic liver condition globally and can begin developing early in life. Though often silent in the initial stages, it may progress to serious complications such as liver inflammation, cirrhosis and even liver failure if left unchecked.
Experts say the risk is not solely genetic. “Epigenetic modifications and shared lifestyle factors contribute to this intergenerational transmission of metabolic risk,” Dr Wadhawan explained, highlighting how the environment before and during conception can shape a child’s long-term metabolic health.
Traditionally, maternal health has been the primary focus in pregnancy planning. However, the study underscores that paternal health is equally important, with the father’s weight and metabolic condition also influencing outcomes in children.
Doctors stress that the risk is preventable. Early interventions aimed at achieving a healthy weight, improving diet, increasing physical activity, and managing underlying health conditions can significantly reduce the likelihood of MASLD in the next generation.
The findings reinforce the growing importance of preconception care, where both partners are encouraged to adopt healthier lifestyles before planning a pregnancy, ensuring better long-term health outcomes for their children.