Lack of stem cells leads to repeat miscarriages: Study


London, Mar 8 (IANS): In a development that could lead to new treatment for those who have suffered failed pregnancies, researchers have discovered that a lack of stem cells in the womb lining causes thousands of women to suffer from recurrent miscarriages.

"We have discovered that the lining of the womb in the recurrent miscarriage patients we studied is already defective before pregnancy,” said lead researcher Jan Brosens, professor at University of Warwick in England.

"I can envisage that we will be able to correct these defects before the patient tries to achieve another pregnancy. In fact, this may be the only way to really prevent miscarriages in these cases," Brosens noted.

The findings were published in the journal Stem Cells.

Between 15-25 percent of pregnancies end in miscarriage and one in 100 women trying to conceive suffer recurrent miscarriages, defined as the loss of three or more consecutive pregnancies, the study pointed out.

The researchers examined tissue samples from the womb lining, donated by 183 women.

The team found that an epigenetic signature -- which is typical of stem cells -- was absent in cultures established from womb biopsies taken from women suffering recurrent miscarriages.

Indeed, fewer stem cells could be isolated from the lining of the womb from recurrent miscarriage patients when compared to women in the study's control group.

The researchers further found that a stem cell shortage accelerates cellular ageing in the womb.

"Cultured cells from women who had had three or more consecutive miscarriages showed that ageing cells in the lining of the womb don't have the ability to prepare adequately for pregnancy," Brosens explained.

  

Top Stories


Leave a Comment

Title: Lack of stem cells leads to repeat miscarriages: Study



You have 2000 characters left.

Disclaimer:

Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. Daijiworld.com will not be responsible for any defamatory message posted under this article.

Please note that sending false messages to insult, defame, intimidate, mislead or deceive people or to intentionally cause public disorder is punishable under law. It is obligatory on Daijiworld to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using daijiworld will be purely at your own risk, and in no way will Daijiworld.com be held responsible.